Miles Morales catapults across the Multiverse, where he encounters a team of Spider-People charged with protecting its very existence. When the heroes clash on how to handle a new threat, Miles must redefine what it means to be a hero.

Still reeling from the loss of Gamora, Peter Quill rallies his team to defend the universe and one of their own – a mission that could mean the end of the Guardians if not successful.